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However, it does not correct the underlying cystic fibrosis transmembrane conductance regulator defect, as shown by the lack of improvement in nasal transepithelial potential difference in cystic fibrosis transmembrane conductance regulator-deficient mice, indicating that epithelial ion transport remains impaired

Iron metabolism plays a central role, as excessive intracellular iron promotes the Fenton reaction, generating lethal amounts of ROS that drive lipid peroxidation [4]

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It also helps the body excrete excess copper so the liver has a chance to heal

Additionally, pairing TMZ with the anti-EGFR antibody nimotuzumab has shown potential for improving treatment effectiveness by targeting the EGFR mutation common in many GBM cases [69]